Clinical application of interferons and their inducers

Cover of: Clinical application of interferons and their inducers |

Published by Dekker in New York .

Written in English

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  • Interferon.,
  • Interferon inducers.,
  • Interferon -- Therapeutic use.,
  • Interferon Inducers.,
  • Interferons.

Edition Notes

Book details

Other titlesInterferon and interferon inducers, clinical applications.
Statementedited by Dale A. Stringfellow.
SeriesClinical pharmacology ;, v. 3
ContributionsStringfellow, Dale A., 1944-
LC ClassificationsQR187.5 .C55 1986
The Physical Object
Paginationxii, 277 p. :
Number of Pages277
ID Numbers
Open LibraryOL2711809M
ISBN 100824775317
LC Control Number86004598

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Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (K), or click Clinical application of interferons and their inducers book a page image below to browse page by : J.B.

Derbyshire. Clinical application of interferons and their inducers. New York: Dekker, © (OCoLC) Online version: Clinical application of interferons and their inducers.

New York: Dekker, © (OCoLC) Document Type: Book: All Authors / Contributors: Dale A Stringfellow. Both the mUltiple actions of interferons (a virtual cascade of biochemical reactions may be induced, as documented herein) and the high visibility of interferon research provided by the millions of dollars invested both by national health agencies and by multinational pharmaceutical companies, contributed to an upsweep in public attention to drug development probably.


Effects of Interferon and Its Inducers on Natural Killer Cell Activity.- I. Discovery and Possible Roles of NK Cells.- II. Mouse NK Cell Activity.- III. Human NK Cell Activity.- H. Summary and Concluding Comments.- References.- 21 Clinical Use of Interferons: Localized Application in Viral Diseases With 3.

A double blind trial was begun on patients with active and quiescent disease. The quiescent group was treated with poly (I)'poly (C) or methyl cellulose, the active group with Experience with clinical applications of interferon and interferon inducers poly (l)'poly (C) Cited by: (Second of Three Parts) Properties of Interferon Cells from several different Clinical application of interferons and their inducers book of animals, including teleost fishes, have been shown to produce interferon Cited by: Carter WA, Horoszewicz JS () Human interferon and its inducers: clinical program overview at Roswell Park Memorial Institute.

Cancer Treat Rep – PubMed Google Scholar Carter WA, Pitha PM, Marshall LW, Tazawa I, Tazawa S, Ts’o POP () Structural requirements of then I rC complex for induction of human by: 9. The first road block in their clinical application was the finding that the interferons were species specific in their biological activity.

With a few rare exceptions, only human or primate interferons are active in human cells, so the single source of interferons for human use in the s and 70s seemed to be primate cells, and the expertise necessary to Cited by: Moreover, there are certain limitations in the clinical usefulness of interferon inducers including a relatively high degree of toxicity and low therapeutic index, hyporeactivity to repeated induction, and potential antibody formation against the inducer by: 1.

COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle.

The use of interferons and interferon inducers to treat human viral and neoplastic diseases is currently under intensive investigation. Considerable. Interferons, Interferon Inducers, and Interferon-Ribavirin in Treatment of Flavivirus-Induced Encephalitis in Mice Pieter Leyssen, 1 Christian Drosten, 2 Marcus Paning, 2 Nathalie Charlier, 1 Jan Paeshuyse, 1 Erik De Clercq, 1 and Johan Neyts 1, *Cited by: At long last, the first book to cover all important areas of interferon science in one volume.

Top scientists, including many pioneers in the field, highlight the role of interferons as research tools and as therapeutic agents in clinical applications. Edited by an experienced interferonologist. The book opens with a chapter that comprehensively reviews the antiviral effects of extracellular double-stranded RNA, the viral toxin.

This is followed by chapters that review the properties of type I and type III interferons, and the role of interferon-stimulated genes. The next five chapters are devoted to understanding the diverse strategies used by clinically relevant human viruses. Immune Interferon: Properties and Clinical Applications is essential reading for anyone working with interferons.

Having developed their own brand of interferon-gamma, the authors have become well known for their research and significant contributions in the fields of molecular biology, biochemistry, and interferon-gamma.

Handbook of Experimental Pharmacology, Continuation of Handbuch der experimentellen Pharmakologie, Today, the basic mood of researchers and clinical investigators, both at the center and on the periphery of interferon studies, is optimistic regarding the future of interferons as therapeutic substances.

Meaning of Interferon 2. Discovery of Interferon 3. Classes 4. Mechanism of Action 5. Receptors and Signal Transduction 6. Role 7. Commercial Production 8.

Clinical Applications. Meaning of Interferon: Interferons (INF) are produced by human and animal cells in minute quantities mainly in response to viral infections, and help eliminate such. Author(s): Stringfellow,Dale A, Title(s): Clinical application of interferons and their inducers/ edited by Dale A.

Stringfellow. Edition: 2nd ed. Country of Publication: United States Publisher: New York: Dekker, c Additional Physical Format: Online version: Interferon and interferon inducers, clinical applications. New York: M. Dekker, © (OCoLC) Interferon has two well defined effects. It inhibits the replication of viruses and it suppresses cell division.

Despite the potential importance of both these properties in medicine, surprisingly little clinical use has yet been made of interferon, one reason being the great difficulty in obtaining sufficient human interferon for experimental by: 6.

Stringfellow, Clinical Applications of Interferon and Their Inducers, 2nd ed () Marcel Dekker New York 8. D.J. Winston, L.J. Eron, M. Ho, Recombinant interferon alpha-2a for treatment of herpes zoster in immunosuppressed patients with cancer Am J Med () Cited by: In: Stringellow DA (ed) Interferon and interferon inducers: clinical applications.

Dekker, New York, pp – Google Scholar Wierenga W, Skulnick HI, Stringfellow DA, Weed SD, Renis HE, Eidson EE () 5-Substituted 2-aminophenyl-4(3H) by: 7. Low molecular weight inducers (Amixin, Cycloferon, Kagocel) that penetrate the blood-brain barrier may be active against viral encephalitis.

At present, clinical trials of IFN inducers are limited, but in the near future, IFN inducers may be used against very different infections and Cited by: and Cytokine then is an appropriate time to review the clinical applications of the accomplish this coherently it is necessary also to review briefly what led to the discovery of interferons, why their clinical applications were so slow in coming, and the impact of interferon research on the biomedical by:    Interferons ά and β bind to the same receptor, which is composed of two subunits  The binding of either interferon- ά or interferon- β to this receptor results in the activation of Janus tyrosine kinases Jak1 and Tyk2, which results in the phosphorylation of signal transducers and activators of transcription 1 and 2.

This review describes a long-standing experience of screening for interferon (IFN) inducers in Russia. IFN inducers represent a special group of potential antiviral compounds. The main requirements for them are (1) high IFN-inducing activity, (2) absence of side effects, (3) wide spectrum of antimicrobial activity, (4) broad therapeutic Cited by: Interferon Interferon and Interferon Inducers.

Clinical Applications. DALE A. STRINGFELLOW, Ed. Dekker, NewYork, xii, pp., illus. $ Modem Pharmacology-Toxicology, vol. The first flowering ofinterferon stud-ies occurred in the late '50's and early '60's. Duringthis time the basic biologi-cal properties ofinterferons were eluci. Interferons: Mechanisms of action and clinical applications Article Literature Review in Current Opinion in Oncology 15(6) December.

The first report on the antitumor effects of interferon α/β (IFN-I) in mice was published 50 years ago. IFN-α were the first immunotherapeutic drugs approved by the FDA for clinical use in cancer. However, their clinical use occurred at a time when most of their mechanisms of action were still unknown.

These cytokines were being used as either conventional cytostatic drugs Author: Eleonora Aricò, Luciano Castiello, Imerio Capone, Lucia Gabriele, Filippo Belardelli. research toward its clinical application. This article is a revised English version of a paper originally published in the Journal of the Japan Medical Association (Vol.

No. 7,pages –). Types and Properties Interferon (IFN) is generally classified into 3 types (Table 1). First, IFN- is produced whenFile Size: 50KB. interferons and their applications handbook of experimental pharmacology Posted By Ry?tar. Shiba Public Library TEXT ID f Online PDF Ebook Epub Library legal analysis and makes no representation as to the accuracy of the status listed expired lifetime application number us06 inventor joseph m cummins start.

Interferons are broadly antiviral, naturally occurring substances, whose exact mechanism of action on virus infections is unknown. Major limitations on the quantities of interferon available for clinical trials have inhibited its development as a therapeutic agent.

The variable nature of virus infections in certain patient populations has also produced difficulties in Cited by: This chapter aims to describe and review the main important cytokines types (notably interferons), including their biological activities, functions and structures.

As a high number of molecules are available, synthesis of the most important cytokines, including tumor factor necrosis, interferons and interleukins will be presented.

Here we also describe the Author: Vinicius L. Ferreira, Helena H.L. Borba, Aline de F. Bonetti, Leticia t, Roberto Pontarolo. Title: Synthetic and Natural Immunomodulators Acting as Interferon Inducers VOLUME: 15 ISSUE: 11 Author(s):Dmytro S. Silin, Oksana V. Lyubomska, Feliks I. Ershov, Valeriy M.

Frolov and Galyna A. Kutsyna Affiliation:Laboratory of Molecular Virology, Medical and Biology Center, School of Biomedical Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 Cited by: Interferons and Interferon Inducers (Frontiers of Biology) [Finter, N.

(ed).] on *FREE* shipping on qualifying offers. Interferons and Interferon Inducers (Frontiers of Biology)Author: N. (ed). Finter. 3 Interferon Inducers. Interferon inducers also proved to be active against flavivirus infections in animals.

Poly(inosinic acid)-poly(cytidylic acid) [Poly(IC)], a synthetic double-stranded RNA and a potent inducer of IFN-α/β, delayed Modoc virus (MODV)–induced morbidity and mortality in SCID mice (Leyssen et al., ). At long last, the first book to cover all important areas of interferon science in one volume.

Top scientists, including many pioneers in the field, highlight the role of interferons as research tools and as therapeutic agents in clinical applications. David F.

Schneider, Herbert Chen, in Abeloff's Clinical Oncology (Fifth Edition), Interferon. Interferon has historical significance as a possible treatment for carcinoid tumors, but its toxicity and relative lack of efficacy limit its use.

In early trials, response rates ranged from 20% to 55%, with response gauged by decrease in symptom burden rather than radiographic.

Name Interferon Inducers Accession Number DBCAT Description. Agents that promote the production and release of interferons. They include mitogens, lipopolysaccharides, and the synthetic polymers Poly A-U and Poly I-C.

Viruses, bacteria, and protozoa have been also known to induce interferons. The goal of this article is to review the nature of cytokines involved in cancer immunotherapy, and to discuss their clinical applications with an overview of the open and recruiting trials of each agent listed on the website as of Janu The article will also emphasize the combination of biological agents, novel Cited by: Interferon is protein or glycoprotein which are secreted by the eukaryotic cells in response to viral infection, some types of cancer, and also to some of other biological inducers.

Therefore interferons can also be used in detecting particular condition or disease such as viral infection, hepatic disease, various cancers and many other.Download Citation | Interferons and Interleukins | Endogenous interferons and interleukins, major protagonists of our defense system, act in a concerted way .

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